3 edition of Transcription Factors and Cell Aging (Journal : Biological Signals, Vol. 5, No. 3, 1996) found in the catalog.
Transcription Factors and Cell Aging (Journal : Biological Signals, Vol. 5, No. 3, 1996)
by S. Karger AG (Switzerland)
Written in English
|Contributions||A. Y. Liu (Editor), D. T. Denhardt (Editor), K. Y. Chen (Editor)|
|The Physical Object|
|Number of Pages||70|
Aging May Mostly be Due to Genes and not Wear and Tear in the Worm, C. elegans. Genes are Controlled by Transcription Factors Remember, genes are simply recipes for proteins. And proteins are the worker bees of the cell. Almost everything that gets done in a cell is done by proteins. Identifying genetic factors that modify an individual's susceptibility to cognitive decline in aging is critical to understanding biological processes involved and mitigating risk associated with a number of age‐related disorders. Recently, heterochromatin protein 1 binding protein 3 (Hp1bp3) was identified as a mediator of cognitive aging.
Ageing or aging (see spelling differences) is the process of becoming term refers especially to human beings, many animals, and fungi, whereas for example bacteria, perennial plants and some simple animals are potentially biologically the broader sense, aging can refer to single cells within an organism which have ceased dividing (cellular senescence) or to the population. Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research.
-Induction by neighboring cells: Signal molecule may bind to a cell-surface receptor; Induction may result from cell-to-cell contact Describe the role of myoD in skeletal muscle development -Gene that in the codes myoD protein, a transcription factor that binds to specific control elements in the enhancers of various target genes and stimulates. Cell expansion is crucial for plant growth. It is well known that the phytohormone ethylene functions in plant development as a key modulator of cell expansion. However, the role of ethylene in the regulation of this process remains unclear. In this study, 2, ethylene-responsive transcripts were identified in rose (Rosa hybrida) petals using transcriptome sequencing and microarray analysis.
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The Final Detail
The forkhead transcription factors (FOXO) have roles in cell cycle arrest and apoptosis, and, as demonstrated by the embryonic lethality of a Foxo1 knockout, these proteins are important in embryogenesis.
There are four FOXO family members—FOXO1, FOXO3, FOXO4, and FOXO6—although expression of the latter is predominantly restricted to. FOXO transcription factors have important roles in many cellular functions, including autophagy. Sirt1 can regulate autophagy indirectly through the deacetylation of the FOXO family members FOXO1 and FOXO3 (Figure A and B).During glucose starvation, Sirt1 induces the deacetylation of FOXO1 and its activation and nuclear translocation in cardiomyocytes (Hariharan et al., ).
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right. Age and wounding are two major determinants for regeneration. In plants, the root regeneration is triggered by wound-induced auxin biosynthesis.
As plants age, the root regenerative capacity gradually decreases. How wounding leads to the auxin burst and how age and wound signals collaboratively regulate root regenerative capacity are poorly understood.
Here, we show that the Cited by: 2. T1 - Transcription factors in mature B-cells during aging. AU - Frasca, Daniela. AU - Riley, Richard L.
AU - Blomberg, Bonnie B. PY - /1/1. Y1 - /1/1. N2 - The purpose of this chapter is to give an overview of the age-related changes in the expression and function of the major transcription factors regulating mature : Daniela Frasca, Daniela Frasca, Richard L.
Riley, Bonnie B. Blomberg. Sensorineural hearing loss affects newborns1 and the majority of the elderly sensations of sound and movement are dependent on highly specialized post-mitotic mechanosensory cells called hair cells (HCs)ian auditory HCs do not regenerate and their loss is a final common pathway in most forms of hearing this reason, understanding the molecular.
FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on diabetic hyperglycemia by reducing hepatic glucose production.
Moreover, all FOXO proteins are considered potential drug targets for drug. Home › Protected: Transcription Factors and Aging (Book Chapter) Protected: Transcription Factors and Aging (Book Chapter) This content is password protected. MYB-related transcription factors are known to regulate different branches of flavonoid metabolism in plants and are believed to play wider roles in the regulation of phenylpropanoid metabolism in general.
Here, we demonstrate that overexpression of two MYB genes from Antirrhinum represses phenolic acid metabolism and lignin biosynthesis in transgenic tobacco plants. Transcription factors regulating -cell function Article Literature Review (PDF Available) in European Journal of Endocrinology (5) December with 51 Reads How we measure 'reads'.
The forkhead box O transcription factors (FOXOs), identified as downstream regulators of the insulin/IGF-1 signaling pathway, control the expression of many genes regulating crucial biological processes such as metabolic homeostasis, redox balance, stress response and cell viability and : Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng.
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and FOX proteins are important to embryonic development.
FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes.
An accumulation in DNA damage and mutations leading to stem cell aging has been one of the earliest theories of aging . DNA damage can be caused by external factors (ionizing.
Inner ear hair cells are non-regenerative mechanosensory cells essential for hearing. Here, with cell-type-specific expression analyses, the authors identify RFX transcription factors as central.
Webb AE, Kundaje A, Brunet A. Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell. ;15(4)–  White JG, Southgate E, Thomson JN, Brenner S.
The structure of the nervous system of the nematode Caenorhabditis elegans. Philos Trans R Soc Lond B Biol Sci. ;():1– Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity.
FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin‐like growth factor signaling. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the Format: Hardcover.
Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their.
Forkhead FOXO Transcription Factors in Development and Disease, Volumethe latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease.
Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights. COBRE Center for Computational Biology of Human Disease (Pilot Award: Genome-wide interplay between the pro-longevity FOXO transcription factors.) 01/01//31/17 Completed Research Support.
Rhode Island Foundation Medical Research Grant. Webb, Ashley (PI) Regulation of human neural stem cell function by the pro-longevity factor FOXO3. FOXO transcription factors play an important role in determining aging and longevity.
The most understood pathway that extends lifespan is the insulin/IGF-1 signaling pathway (IIS) that influences longevity in worms, mice, flies, and mammals [xvii].The age-associated effects on the expression and function of the transcription factors NF-κ B and Pax-5 are also described. Blimp-1 seems not to be modified by aging.
For other transcription factors relevant for mature B-cell functions, such and IRF4 and Notch2, no effects of aging have been reported so far. Plant cell Animal cell 3 4. Cell Aging Mitochondria DNA damage, repair and mutagenesis Gerontogenes and age related diseases Signal transduction Cell cycle regulation and cancer Telomeres as molecular cell clock Age related transcription and translation changes The .